CAY10649
Product Specifications
CAS Number
1272519-89-7
Target
Others, Monoamine Oxidase
Related Pathways
Others, Neuroscience
Bioactivity
1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.
Smiles
C(=C/1\SC(=NC1=O)C2=CC=C(Cl)C=C2)\C3=CC=C(OC)C=C3
Molecular Formula
C17H12ClNO2S
Molecular Weight
329.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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