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URB447

Product Specifications

CAS Number

1132922-57-6

Target

Others, Cannabinoid Receptor

Related Pathways

Others, GPCR/G Protein

Bioactivity

URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].

Smiles

C(N1C(=C(N)C(C(=O)C2=CC=CC=C2)=C1C)C3=CC=CC=C3)C4=CC=C(Cl)C=C4

Molecular Formula

C25H21ClN2O

Molecular Weight

400.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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