NBD-FTY720 phenoxy hydrochloride
Product Specifications
CAS Number
2319882-09-0
Target
Others
Related Pathways
Others
Bioactivity
FTY720, an immune modulator, down-regulates sphingosine-1-phosphate (S1P) receptors, enhances the activity of sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1, and inhibits cytosolic phospholipase A2 activity. Its efficacy relies on in vivo phosphorylation by sphingosine kinases, resulting in FTY720-phosphate which also down-regulates S1P receptors. NBD-FTY720, a fluorescently-labeled analog of FTY720, retains the hydroxy methyl side chain targeted for phosphorylation, suggesting potential phosphorylation in vivo.
Smiles
N(=O)(=O)C=1C=2C(C(NCCCCCCOC3=CC=C(CCC(CO)(CO)N)C=C3)=CC1)=NON2.Cl
Molecular Formula
C23H31N5O6?HCl
Molecular Weight
510
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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