Halofuginone hydrochloride
Product Specifications
CAS Number
1217623-74-9
Target
Sodium Channel, DNA/RNA Synthesis, Others, Parasite, Calcium Channel, TGF-beta/Smad
Related Pathways
Membrane transporter/Ion channel, Others, Metabolism, Stem Cells, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.
Smiles
Cl.OC1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Molecular Formula
C16H18BrCl2N3O3
Molecular Weight
451.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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