What is the catalog number for Halofuginone hydrochloride?

The catalog number for Halofuginone hydrochloride is T84443.

What sizes are available for Halofuginone hydrochloride?

Halofuginone hydrochloride is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does Halofuginone hydrochloride come in?

Halofuginone hydrochloride is available in 2 different pack sizes.

Is Halofuginone hydrochloride in stock?

Halofuginone hydrochloride is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Halofuginone hydrochloride?

Halofuginone hydrochloride is manufactured by Molfinity.

What is the estimated delivery time for Halofuginone hydrochloride?

Estimated delivery time for Halofuginone hydrochloride is approximately 10 business day(s), depending on your location.

Halofuginone hydrochloride

Product Specifications

CAS Number

1217623-74-9

Target

Sodium Channel, DNA/RNA Synthesis, Others, Parasite, Calcium Channel, TGF-beta/Smad

Related Pathways

Membrane transporter/Ion channel, Others, Metabolism, Stem Cells, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.