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LY303511 hydrochloride

Product Specifications

CAS Number

854127-90-5

Target

Others, Potassium Channel, TNF

Related Pathways

Apoptosis, Membrane transporter/Ion channel, Others

Bioactivity

LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.

Smiles

Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1

Molecular Formula

C19H20Cl2N2O2

Molecular Weight

379.28

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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