LY303511 hydrochloride
Product Specifications
CAS Number
854127-90-5
Target
Others|||Potassium Channel|||TNF
Related Pathways
Apoptosis|||Membrane transporter/Ion channel|||Others
Bioactivity
LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.
Smiles
Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
Molecular Formula
C19H20Cl2N2O2
Molecular Weight
379.28
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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