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VU 0546110

Product Specifications

CAS Number

1421523-00-3

Target

Others, Potassium Channel

Related Pathways

Others, Membrane transporter/Ion channel

Bioactivity

VU 0546110, a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50= 64 μM), demonstrates 40-fold selectivity over SLO1. It effectively blocks both heterologous SLO3 currents and endogenous K+ currents, inhibiting sperm hyperpolarization and preventing hyperactivated mobility.

Smiles

COC1=CC=C(SCC2CCN(CC2)C(=O)CC2=CC=C(C=C2)S(=O)(=O)C(C)C)C=C1

Molecular Formula

C24H31NO4S2

Molecular Weight

461.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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