VU 0546110
Product Specifications
CAS Number
1421523-00-3
Target
Others|||Potassium Channel
Related Pathways
Others|||Membrane transporter/Ion channel
Bioactivity
VU 0546110, a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50= 64 ?M), demonstrates 40-fold selectivity over SLO1. It effectively blocks both heterologous SLO3 currents and endogenous K+ currents, inhibiting sperm hyperpolarization and preventing hyperactivated mobility.
Smiles
COC1=CC=C(SCC2CCN(CC2)C(=O)CC2=CC=C(C=C2)S(=O)(=O)C(C)C)C=C1
Molecular Formula
C24H31NO4S2
Molecular Weight
461.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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