EIF4A i28
Product Specifications
CAS Number
2861994-92-3
Target
Others
Related Pathways
Others
Bioactivity
EIF4A i28, an inhibitor of the eukaryotic initiation factor-4A (eIF4A) with an IC50 of 8.60 μM in an eIF4A ATPase assay, effectively reduces the viability of BJAB Burkitt lymphoma cells, as indicated by an EC50 of 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. This compound functions as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.
Smiles
CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1
Molecular Formula
C24H20N2O5
Molecular Weight
416.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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