BDW568
Product Specifications
CAS Number
335401-44-0
Target
Others, STING
Related Pathways
Others, Immunology/Inflammation
Bioactivity
BDW568, a prodrug of BDW-OH, serves as a stimulator of interferon genes (STING) agonist. This compound effectively induces STING transcriptional activity, evidenced by a reporter assay in THP-1 cells, with an EC50 value of 7.6 μM. Furthermore, at a concentration of 50 μM, BDW568 prompts phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) within THP-1 cells, showcasing its biochemical activity in cellular signaling pathways.
Smiles
O=C(OC)CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3
Molecular Formula
C12H12N4O2S2
Molecular Weight
308.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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