Plipastatin A1

Plipastatin A1, a lipopeptide isolated from B. cereus, demonstrates enzyme inhibitory and immunosuppressant properties. It effectively inhibits enzymes phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD) with half-maximal inhibitory concentrations (IC50s) of 2.9, 1.3, and 1.4 μM, respectively. Additionally, at a concentration of 100 μg/ml, plipastatin A1 inhibits lipopolysaccharide (LPS) -induced B cell blastogenesis and T cell blastogenesis triggered by concanavalin A. In vivo studies reveal that a dose of 0.1 mg/animal effectively suppresses delayed-type hypersensitivity in mice.

O=C([C@H](NC([C@@H](NC(C[C@@H](CCCCCCCCCCCCC)O)=O)CCC(O)=O)=O)CCCN)N[C@@H](CC1=CC=C(OC([C@@]([C@@H](C)CC)([H])NC([C@@H](CC2=CC=C(O)C=C2)NC3=O)=O)=O)C=C1)C(N[C@@]([C@H](O)C)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C)C(N4[C@@](C(N[C@H]3CCC(N)=O)=O)([H])CCC4)=O)=O)=O)=O