SP-A (196-215) (human) TFA

Surfactant protein A (SP-A) (196-215) is a synthetic peptide derived from the C-terminal carbohydrate recognition domain of human SP-A, specifically amino acids 196-215. This peptide suppresses LPS-induced TNF-α release in JAWSII mouse dendritic cells at 1 and 10 μM concentrations and promotes phagocytosis of P. aeruginosa at a 75 μM concentration. Furthermore, intratracheal administration of SP-A (196-215) at a dose of 50 μg per animal reduces disease severity and lung colony-forming units in mice infected with P. aeruginosa.

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