Sp-Thymidine-5'-O- (1-thiotriphosphate) sodium
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
Sp-Thymidine-5'-O- (1-thiotriphosphate) (Sp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 μM in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-α-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM.
Smiles
O[C@@H](C1)[C@H](O[C@H]1N2C=C(C)C(NC2=O)=O)CO[P@@](OP([O-])(OP([O-])([O-])=O)=O)([S-])=O.[Na+].[Na+].[Na+].[Na+]
Molecular Formula
C10H13N2O13P3S.4Na
Molecular Weight
586.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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