Sp-Adenosine-5'-O- (1-thiotriphosphate) sodium
Product Specifications
Target
Others
Related Pathways
Others
Bioactivity
Sp-Adenosine-5'-O- (1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells harboring the P2Y1 receptor with an EC50 of 9.4 nM for the human receptor. It also inhibits ADP-induced human isolated platelet aggregation with a Ki value of 4 μM and prompts relaxation in carbamoylcholine-tightened guinea pig taenia coli, achieving an EC50 of 426 nM.
Smiles
O[C@@H]1[C@@H](CO[P@@](OP(OP([O-])([O-])=O)([O-])=O)([S-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]
Molecular Formula
C10H12N5O12P3S.4Na
Molecular Weight
611.18
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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