2-Chloroadenosine-5'-O-diphosphate sodium

Product Specifications

CAS Number

82927-78-4

Target

Others, AChR, HSP

Related Pathways

Cytoskeletal Signaling, Others, Neuroscience, Metabolism

Bioactivity

2-Chloroadenosine-5'-O-diphosphate, a purine nucleotide adenosine 5'diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered by prostaglandin E2 (PGE2), in a concentration-dependent manner within isolated human platelet-rich plasma. Additionally, this compound facilitates the relaxation of precontracted isolated guinea pig taenia coli strips (pD2 = 6.74) and reduces arterial blood pressure in rats. Moreover, 2-Chloroadenosine-5'-O-diphosphate significantly inhibits the ATPase activity of mortalin, a member of the heat shock protein 70 (Hsp70) family, with an apparent Ki of 45.05 μM for the human enzyme.

Smiles

O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP([O-])([O-])=O)=O)O[C@H]1N2C=NC3=C(N)N=C(Cl)N=C32.[Na+].[Na+].[Na+]

Molecular Formula

C10H11ClN5O10P2.3Na

Molecular Weight

527.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C