Shepherdin TFA

Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 μM concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.

O=C(N[C@H](C(O)=O)CC(C)C)[C@@H](NC([C@H](C)NC([C@H](CS)NC(CNC([C@H](CO)NC([C@H](CO)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2.OC(C(F)(F)F)=O