Tiger17 TFA

Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 μg/ml concentrations, and promotes HaCaT cell migration at 20 μg/ml. Additionally, Tiger17 augments RAW 264.7 macrophages' recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 μg/ml, it accelerates wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.

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