SMAP 29 (ovine) TFA

SMAP 29, a bactericidal antimicrobial peptide and a cleavage product from the C-terminus of an ovine cathelicidin prepropeptide, is effective against P. aeruginosa strain PAO1 in both low- and high-salt conditions, as demonstrated in an energy-dependent luminescence assay with half-maximal effective concentrations (EC50s) of 0.05 and 0.06 μM, respectively. Additionally, it induces hemolysis in ovine red blood cells in a concentration-dependent manner.

OC(C(F)(F)F)=O.O=C(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC2=CC=C(O)C=C2)C(NCC(N3CCC[C@H]3C(N[C@]([C@H](O)C)([H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@H](C(NCC(O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)([H])[C@@H](C)CC)=O)([H])[C@@H](C)CC)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)[C@H](CCCNC(N)=N)N[H]