Tat-βsyn-degron TFA

Tat-?syn-degron, an ?-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an ?-synuclein binding domain (?syn) representing amino acids 36-45 of ?-synuclein, and a proteasomal targeting domain (degron) . It effectively binds to recombinant ?-synuclein, demonstrating a significant reduction in ?-synuclein levels in primary rat cortical neuron cultures.

O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(O)C=C2)N[H].OC(C(F)(F)F)=O