F1 TFA

F1, an anti-inflammatory peptide, incorporates the HIV-1 Tat protein transduction domain linked with a 15-amino acid sequence from residues 46-60 of the inhibitor of NF-?B kinase-interacting peptide (IKIP) . It effectively blocks LPS-induced phosphorylation of I?B kinase ? (IKK?) and IKK?, along with the nuclear translocation of NF-?B (p65) in mouse peritoneal macrophages at 5 µM concentration. F1, administered at 5 mg/kg in vivo, significantly reduces IL-6, TNF-?, and IL-1? serum levels and enhances survival in a mouse sepsis model induced by LPS.

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