α-Helical CRF (9-41) TFA

α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 μM, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 μmol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 μmol/kg in rats and demonstrates the ability to enhance social interaction times in a rat model addressing nicotine-induced conditioned anxiety, in addition to decreasing binge-like ethanol consumption in mice.

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