12R-LOX-IN-1
Product Specifications
CAS Number
857758-13-5
Target
Others, DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others
Bioactivity
12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 μM, is an inhibitor of 12R-LOX. It suppresses hyperproliferation and colony formation in Imiquimod-induced psoriatic keratinocytes, and reduces levels of reactive oxygen species, Ki67, IL-17A, TNF-α, and IL-6. This compound has utility in antipsoriatic research [1].
Smiles
OC=1C=CC=2N=C(C=CC2C1)C=3C=CC=CC3O
Molecular Formula
C15H11NO2
Molecular Weight
237.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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