A3373
Product Specifications
CAS Number
2324948-66-3
Target
Phospholipase
Related Pathways
Metabolism
Bioactivity
A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of 325 nM for PLD1 and 15.15μM for PLD2. This compound effectively suppresses lipopolysaccharide (LPS) -induced immune responses and is implicated in key processes of autoimmune arthritis, bone demineralization, and osteoclastogenesis [1] [2].
Smiles
O=C(NC=1C=C(C=C(C1)C(F)(F)F)C(F)(F)F)C2=CC=3C=C(F)C=CC3N2
Molecular Formula
C17H9F7N2O
Molecular Weight
390.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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