Amyloid-Forming peptide GNNQQNY
Product Specifications
CAS Number
339091-39-3
Target
Beta Amyloid
Related Pathways
Neuroscience
Bioactivity
Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable ?-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid ?-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement.
Smiles
[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)CC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O
Molecular Formula
C33H48N12O14
Molecular Weight
836.81
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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