D359-0396
Product Specifications
CAS Number
1031977-31-7
Target
Pyroptosis|||NOD-like Receptor (NLR)
Related Pathways
Apoptosis|||Immunology/Inflammation
Bioactivity
D359-0396, an orally active NLRP3 inflammasome inhibitor, mitigates pyroptosis and reduces IL-1? release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. The compound is effective in alleviating Experimental Autoimmune Encephalomyelitis (EAE) and enhances survival following septic shock in mice [1].
Smiles
O=C1C2=CN3C=4C=CC=CC4NC(C5=CC=C(C=C5)C(C)C)C3=C2N(C(=O)N1C)C
Molecular Formula
C24H24N4O2
Molecular Weight
400.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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