Dargistotug
Product Specifications
CAS Number
2649362-29-6
Target
Immunology/Inflammation related
Related Pathways
Immunology/Inflammation
Purity
0.985
Bioactivity
Dargistotug (M-6223), a fully human IgG1 monoclonal antibody, specifically binds to TIGIT (T cell immune receptor with Ig domain and ITIM), an inhibitory checkpoint receptor that plays a critical role in immune regulation. Dargistotug (M-6223) mitigates NK cell depletion, enhances cytokine secretion, modulates effector T cell activity, and increases regulatory T cell (Treg) function, thereby contributing to the broader immunosuppressive environment. Dargistotug (M-6223) has thus become an important agent in research focused on immune checkpoint inhibition.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
132433-ML750 100 µL
RCHY1 (RING Finger and CHY Zinc Finger Domain-containing Protein 1, Androgen Receptor N-terminal-interacting Protein, CH-rich-interacting Match with PLAG1, E3 Ubiquitin-protein Ligase Pirh2, RING Finger Protein 199, Zinc Finger Protein 363, p53-induced RING-H2 Protein, hPirh2, ARNIP, CHIMP, PIRH2, RNF199, ZNF363) (MaxLight 750) discontinued
Sign In for Pricing
View Details 
LS005794-100ug 100 µg
SAP1 (PTPRH) (NM_002842) Human Over-expression Lysate
Sign In for Pricing
View Details 
P3109-08-01 250 µL
Parathyroid Hormone, NT (PTH) (Not for Export EU)
Sign In for Pricing
View Details MBS6323580-01 0.1 mL
MYSM1, NT (MYSM1, KIAA1915, Histone H2A deubiquitinase MYSM1, Myb-like, SWIRM and MPN domain-containing protein 1) (MaxLight 650)
Sign In for Pricing
View Details