DQP-997-74
Product Specifications
CAS Number
2377187-09-0
Target
Others, iGluR
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Others
Bioactivity
Dihydroquinoline-pyrazoline DQP-997-74 (compound 2i) is a selective N-methyl-d-aspartate receptor (NMDAR) inhibitor that preferentially targets GluN2C/D subunits, with IC50 values of 0.069 μM and 0.035 μM, respectively, and possesses blood-brain barrier permeability. It enhances its inhibitory potency in a time-dependent manner when combined with the agonist glutamate, reducing epileptogenic events in a murine model of tuberous sclerosis complex (TSC) -induced epilepsy. DQP-997-74 is potentially applicable for the study of NMDAR-related neurological diseases [1].
Smiles
O=C(O)CC(F)(F)C(=O)N1N=C(C=2C(=O)NC=3C=CC=CC3C2C=4C=CC(Cl)=CC4)CC1C5=CC=C(Cl)C=C5
Molecular Formula
C28H19Cl2F2N3O4
Molecular Weight
570.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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