FTO-IN-10
Product Specifications
Target
Autophagy
Related Pathways
Autophagy
Bioactivity
FTO-IN-10 (compound 7), a potent inhibitor of the human demethylase FTO (fat mass and obesity-associated protein), exhibits an IC50 of 4.5 μM. It interacts with the binding pocket of FTO's structural domain II via hydrophobic and hydrogen bonding interactions, and promotes DNA damage and autophagic cell death in A549 cells [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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