Ganglioside GM2

Ganglioside GM2 is a component of the cell membrane's glycosphingolipid bilayer and a human tumor antigen (OFA-I-1) . It accumulates and increases in models of Sandhoff disease, Niemann-Pick disease, and Tay-Sachs disease, among others. Ganglioside GM2 binds to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, thereby promoting tumor cell migration and invasion.

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