Glycyrrhizin-6′′-methylester

Glycyrrhizin-6''-methylester (compound 22), isolated from licorice root, functions as an aglycone to form methyl glucuronate, imparting a sweet, licorice flavor without bitterness. The free carboxyl group on the cone-bound glucuronic acid moiety is critical in contributing to the compound's natural sweetness and licorice taste [1].

C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O[C@H]4[C@H](O[C@@H]5O[C@H](C(OC)=O)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4)CC3)[H])(C(=O)C=C6[C@@]2(C)CC[C@]7(C)[C@]6(C[C@](C(O)=O)(C)CC7)[H])[H]