GW274150 dihydrochloride
Product Specifications
CAS Number
438542-17-7
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Bioactivity
GW274150 (dihydrochloride) is a potent and selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, and an ED50 of 1.15 μM for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species, and has shown protective effects in acute lung injury inflammation models [1] [2] [3].
Smiles
OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl
Molecular Formula
C8H19Cl2N3O2S
Molecular Weight
292.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
245443 200 µL
DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10, DKFZp434J1813, ERdj5, JPDI, MGC104194)
Sign In for Pricing
View Details 
MBS1341662-01 0.02 mg (E-Coli)
Recombinant Dictyostelium discoideum Vacuolar protein sorting-associated protein 26 (vps26)
Sign In for Pricing
View Details MBS1341662-02 0.02 mg (Yeast)
Recombinant Dictyostelium discoideum Vacuolar protein sorting-associated protein 26 (vps26)
Sign In for Pricing
View Details MBS1341662-03 0.1 mg (E-Coli)
Recombinant Dictyostelium discoideum Vacuolar protein sorting-associated protein 26 (vps26)
Sign In for Pricing
View Details MBS1341662-04 0.1 mg (Yeast)
Recombinant Dictyostelium discoideum Vacuolar protein sorting-associated protein 26 (vps26)
Sign In for Pricing
View Details