GW274150 dihydrochloride
Product Specifications
CAS Number
438542-17-7
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Bioactivity
GW274150 (dihydrochloride) is a potent and selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 ?M and Kd of 40 nM for human iNOS, and an ED50 of 1.15 ?M for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species, and has shown protective effects in acute lung injury inflammation models [1] [2] [3].
Smiles
OC([C@@H](N)CCSCCNC(C)=N)=O.Cl.Cl
Molecular Formula
C8H19Cl2N3O2S
Molecular Weight
292.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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