HDAC1/CDK7-IN-1
Product Specifications
CAS Number
2987905-95-1
Target
Apoptosis, HDAC, CDK
Related Pathways
Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
HDAC1/CDK7-IN-1 (compound 8e) is a dual inhibitor of CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM, respectively. It suppresses the proliferation of cancer cell lines such as MDA-MB-231, MCF-7, A549, and HCT-116, induces cell cycle arrest and apoptosis in HCT-116 cells, and impedes their migration [1].
Smiles
O=C(NC=1C=CC=C(C1)NC=2N=CC(Cl)=C(N2)C3=CNC=4C=CC=CC43)C=5C=CC=C(C5)NC(=O)CCCCCCC(=O)NO
Molecular Formula
C33H32ClN7O4
Molecular Weight
626.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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