HIF-1α-IN-6

HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α with IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively, and it suppresses HIF-1α expression by reducing HIF-1α mRNA levels [1].