HMGB1-IN-2
Product Specifications
Target
Interleukin, Others, Apoptosis, Caspase, NF-κB
Related Pathways
Apoptosis, NF-κB, Proteases/Proteasome, Immunology/Inflammation, Others
Bioactivity
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, showing no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At 30 μM, it reduces IL-1β, TNF-α, and caspase-1 p20 levels, inhibits NF-κB p65 phosphorylation, and provides anti-apoptotic effects. In vivo, 15 mg/kg of HMGB1-IN-2 administered intraperitoneally alleviates kidney injury in a mouse model of septic acute kidney injury. Additionally, it inhibits Huh7 and A549 cells with IC50 values of 77.0 μM and 82.0 μM, respectively [1].
Smiles
COc1ccc(/C=C/C(O[C@H]2CC[C@]3(C(C2(C)C)CC[C@@]4([C@@H]3C(C=C5C6C[C@@](C(OCC7=NN(C8OC(C)C(OC(C)=O)C(OC(C)=O)C8)N=C7)=O)(CC[C@@]6(CC[C@]54C)C)C)=O)C)C)=O)cc1
Molecular Formula
C53H71N3O11
Molecular Weight
926.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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