JH-131e-153
Product Specifications
CAS Number
742104-91-2
Target
Others, PKC
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Others
Bioactivity
JH-131e-153, a diacylglycerol (DAG) -lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound's C1 domain shares sequence and structure homology with protein kinase C (PKC), with an activation preference of PKCα>Munc13-1>PKCε. JH-131e-153 is implicated in the modulation of neuronal processes and holds potential for research in neurodegenerative diseases [1].
Smiles
C(OC(C(C)(C)C)=O)[C@]1(CO)C\C(=C\CC(CC(C)C)CC(C)C)\C(=O)O1
Molecular Formula
C22H38O5
Molecular Weight
382.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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