MC-VC-PABC-C6-alpha-Amanitin

MC-VC-PABC-C6-alpha-Amanitin is an antibody-drug conjugate that combines the anticancer toxin alpha-Amanitin with the monoclonal antibody MC-VC-PABC-C6. Alpha-Amanitin, a potent inhibitor of RNA polymerase IIα, enables the conjugate to selectively target and recognize HER2-positive tumor cells, making it a valuable research tool in the study of breast and gastric cancers [1].

O=S1C2=C(C=3C(N2)=CC(OCCCCCCNC(OCC4=CC=C(NC([C@H](NC([C@H](NC(CCCCCN5C(=O)C=CC5=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C4)=O)=CC3)C[C@@]6(NC(=O)[C@]([C@H]([C@H](CO)O)C)(NC(=O)[C@]7(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@](C1)(NC(=O)CNC(=O)[C@]([C@H](CC)C)(NC(=O)CNC6=O)[H])[H])C[C@H](O)C7)[H])[H])[H]