MK-2206 free base
Product Specifications
CAS Number
1032349-93-1
Target
Akt, Apoptosis, Autophagy
Related Pathways
PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Autophagy, Apoptosis
Bioactivity
MK-2206 free base is a potent, selective, and orally administered allosteric Akt inhibitor with IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It demonstrates sensitivity in various breast cancer cell lines, including those with PIK3CA mutations and PTEN loss, indicating its potential for anticancer activities [1] [2].
Smiles
O=C1NN=C2C=3C=C(C=4C=CC=CC4)C(=NC3C=CN12)C=5C=CC(=CC5)C6(N)CCC6
Molecular Formula
C25H21N5O
Molecular Weight
407.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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