MOG (92–106), mouse, rat

MOG (92–106), mouse, rat, is a biologically active peptide corresponding to the fragment of amino acids 92 to 106 in myelin oligodendrocyte glycoprotein (MOG) from mice and rats. Mice subjected to MOG (92–106) -induced experimental autoimmune encephalomyelitis show substantial B cell reactivity to secondary myelin antigens. Although this MOG fragment elicits only modest T cell responses, the resultant autoimmunity is profoundly severe. The peptide demonstrates encephalitogenic properties in various species, including SJL mice, DA rats, and rhesus monkeys.

[C@@H](CC1=CC=CC=C1)(NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC(CNC(CNC([C@@H](NC([C@H](CC(O)=O)N)=O)CCC(O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CS)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)CO)=O)=O)CC(O)=O)=O)CCCNC(=N)N)=O