N3-PEG3-VC-PAB-MMAF

N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate for antibody-drug conjugates (ADCs) comprising the ADC linker N3-PEG3-VC-PAB and the microtubule-disrupting agent MMAF [1]. This click chemistry reagent features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules and can also perform strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds presenting DBCO or BCN groups.

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