PI3Kα-IN-14
Product Specifications
Target
PI3K|||Apoptosis
Related Pathways
PI3K/Akt/mTOR signaling|||Apoptosis
Bioactivity
PI3K?-IN-14 (compound F8), a potent PI3K? inhibitor, exhibits an IC50 value of 0.14 nM and significantly reduces mitochondrial membrane potential, leading to G1 phase cell cycle arrest and apoptosis in U87-MG cells. It also shows substantial antiproliferative effects against various tumor cell lines, including PC-3 (IC50 of 0.28 ?M), HCT-116 (IC50 of 0.57 ?M), and U87-MG (IC50 of 1.37 ?M) [1].
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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