PKCd (8-17)

Product Specifications

CAS Number

379711-25-8

Target

PKC

Related Pathways

Cytoskeletal Signaling|||Chromatin/Epigenetic

Bioactivity

PKCd (8-17) is a bioactive peptide originating from the V1 domain of protein kinase C (PKC) d. It impedes phorbol 12-myristate 13-acetate (PMA) -stimulated PKCd translocation and activation, which mitigates ischemic injury in cardiac and cerebral cells, promotes fibroblast proliferation, and suppresses graft coronary artery disease in [mouse models].

Smiles

[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@H](CO)N)=O)=O)CC(N)=O)=O)CO)=O