Proteasome-activating peptide 1

Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular model of amyotrophic lateral sclerosis [1].

C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@H]([C@H](CC)C)N)=O)CCC1)CCCNC(=N)N)=O)CS)=O)CCCNC(=N)N)=O)CCCCN)=O)CCSC)(=O)N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CS)=O)CCSC)=O)CCCCN)=O)C(C)C)=O)=O)CCC2