RFRP-3 (rat) acetate

RFRP-3 (rat) acetate is an RFamide-family neuropeptide characterized by a C-terminal Arg-Phe-NH2 motif, consisting in rats of the 12-residue sequence VPNLPQRF-NH2; RFRP-3 (rat) acetate (420088-80-8 Free base) exhibits functional specialization compared with related peptides such as NPFF and PrRP, acting primarily as an inhibitor of reproductive signaling; its neurons are localized to the dorsomedial hypothalamus and project to GnRH neurons and the median eminence, making RFRP-3 a critical tool for studying hypothalamic regulation of fertility, neuroendocrine signaling, and peptide evolution within the RFamide family.

C[C@H](N)C(N[C@@H](CC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@@H](CC1=CN=CN1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O