RTRD01
Product Specifications
CAS Number
1332175-56-0
Target
Others|||Beta Amyloid
Related Pathways
Others|||Neuroscience
Bioactivity
RTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. The compound can partially disrupt the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1].
Smiles
O=C(N)C=1N=C(C=NC1)N2CCCC(CO)(CC3=CC=C(F)C=C3)C2
Molecular Formula
C18H21FN4O2
Molecular Weight
344.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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