Sotiburafusp alfa
Product Specifications
CAS Number
2637466-37-4
Target
PD-1/PD-L1|||VEGFR
Related Pathways
Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Immunology/Inflammation|||Apoptosis
Bioactivity
Sotiburafusp alfa is a humanized bispecific fusion protein comprising a VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) connected through a 101 GGSGGSGGSGGSGGS 115 peptide linker to the N-terminus (116-564) of a humanized IgG1-kappa anti-human PD-L1 heavy chain with L352>A and L353>A mutations. Additionally, sotiburafusp alfa functions as an angiogenesis inhibitor [1].
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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