SPLA2-IIA Inhibitor
Product Specifications
CAS Number
236394-37-9
Bioactivity
The sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK, specifically cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2), which interacts with human IIA phospholipase A2 (hGIIA) to impede its ester bond hydrolyzing function. As part of the esterase superfamily, sPLA2 enzymatically cleaves the sn-2 ester bond in glycerophospholipids, releasing arachidonic acid and lysophospholipids[1].
Smiles
C(C1=CC2=C(C=C1)C=CC=C2)[C@@H]3NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC5=C(C=C4)C=CC=C5)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC3=O
Molecular Formula
C41H50N8O6
Molecular Weight
750.89
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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