SR-1114
Product Specifications
CAS Number
2769141-82-2
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
Smiles
O=C(NC1CCC1)C=2C=CC3=NC(=CN3C2)C=4C=CC=C(C4)NS(=O)(=O)NCCOCCOCCNC(=O)COC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7
Molecular Formula
C39H42N8O11S
Molecular Weight
830.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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