SWTX-143
Product Specifications
CAS Number
2766575-48-6
Target
YAP
Related Pathways
Stem Cells
Bioactivity
SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional activity of the YAP/TAZ-TEAD complex and demonstrating antitumor activity [1].
Smiles
O=C(C=C)NC1CC=2C(N)=CC=CC2N(C3=CC=C(C=C3)C(F)(F)F)C1
Molecular Formula
C19H18F3N3O
Molecular Weight
361.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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